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Structural conservation of residues in BH1 and BH2 domains of Bcl-2 family proteins

✍ Scribed by Gangenahalli U. Gurudutta; Yogesh Kr Verma; Vimal Kishor Singh; Pallavi Gupta; H.G. Raj; R.K. Sharma; Ramesh Chandra

Book ID: 116465659
Publisher: Elsevier Science
Year: 2005
Tongue: English
Weight: 347 KB
Volume: 579
Category: Article
ISSN: 0014-5793
DOI: 10.1016/j.febslet.2005.05.015

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## Abstract Solid phase synthesis of BH4, the 26 amino‐acid domain (^6^RTGYDNREIVMKYIHYKLSQRGYEWD^31^) of the anti‐apoptotic Bcl‐2 protein has been accomplished using Fmoc chemistry. The use of peculiar cleavage conditions provided high yields after purification such that tens to hundreds of mg cou