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Structural Consequences of the Ionization of Internal Lys Residues in a Protein

✍ Scribed by Chimenti, Michael S.; Khangulov, Victor; Robinson, Aaron C.; Schlessman, Jamie L.; Majumdar, Ananya; Garcia-Moreno E., Bertrand


Book ID
122237856
Publisher
Biophysical Society
Year
2009
Tongue
English
Weight
38 KB
Volume
96
Category
Article
ISSN
0006-3495

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## Abstract The human immunodeficiency virus type 1 (HIV‐1) protein U (VpU) is an accessory protein responsible for enhancement of viral particle release and down regulation of the T‐lymphocyte coreceptor CD4. Direct binding between the cytoplasmic domains of CD4 and VpU as well as phosphorylation