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Structural consequences of a one atom mutation on aspartate transcarbamylase from E. coli

โœ Scribed by J. Cherfils; R.M. Sweet; S.A. Middleton; E.R. Kantrowitz; P. Tauc; P. Vachette


Book ID
115922439
Publisher
Elsevier Science
Year
1989
Tongue
English
Weight
559 KB
Volume
247
Category
Article
ISSN
0014-5793

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Aspartate transcarbamylase is a large (310 kD), multisubunit protein that binds substrates cooperatively and undergoes a large change in quaternary structure when substrates bind. The forces that drive this transition are poorly understood. We evaluated the electrostatic component of these forces by