Structural comparisons between chicken low molecular weight immunoglobulin heavy chains and human γ chains

✍ Scribed by James C. Travis; Bob G. Sanders

• Book ID: 104785702
• Publisher: Springer
• Year: 1973
• Tongue: English
• Weight: 581 KB
• Volume: 8
• Category: Article
• ISSN: 0006-2928
• DOI: 10.1007/bf00487344

✦ Synopsis

Comparisons between chicken low molecular weight immunoglobulin (LMW Ig) and human 7 heavy chains as to molecular weights, amino acid compositions, tryptic peptide maps, and CHO-peptide sequences revealed significant differences. The molecular weight of the chicken heavy chain, 60,000, is approximately 10,000 more than that for human 7, indicating up to 100 more amino acids, including three more cysteine residues. Tryptie peptide map comparisons revealed no common peptides as to mobilities and amino acid compositions. The sequence of the chicken heavy chain CHO-peptide, Gly-Trp-Val-Ser-Asx-Thr-Cys, exhibits little homology with the CHO-peptides or eysteine peptides of human T or It heavy chains. The implications of these structural differences between chicken and human heavy chains with regard to evolutionary relatedness and secondary biological functions are discussed.