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Structural characterization of the human DNA topoisomerase I gene promoter

✍ Scribed by Norbert KUNZE; Michael KLEIN; Arndt RICHTER; Rolf KNIPPERS


Book ID
115127934
Publisher
John Wiley and Sons
Year
1990
Tongue
English
Weight
965 KB
Volume
194
Category
Article
ISSN
1432-1327

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## Abstract In this report we show that human DNA Topoisomerase I (Top1) forms DNA‐protein adducts with nicked and gapped DNA structures lacking a conventional Top1 cleavage site. The radioactively labeled crosslinking products were identified by SDS‐gel electrophoresis. The chemical structure of t