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Structural characterization of prazosin hydrochloride and prazosin free base

✍ Scribed by Chernyshev, Vladimir V. (author);Stephens, Peter W. (author);Yatsenko, Alexandr V. (author);Ryabova, Olga B. (author);Makarov, Vadim A. (author)

Publisher
John Wiley and Sons Inc.
Year
2004
Tongue
English
Weight
121 KB
Volume
93
Category
Article
ISSN
0022-3549

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✦ Synopsis

The three-dimensional solid-state structures of prazosin hydrochloride, C 19 H 22 N 5 O 4 ΓΎ Á Cl Γ€ (A), and prazosin free base, C 19 H 21 N 5 O 4 (B), have been determined by synchrotron X-ray powder diffraction. A and B crystallize in triclinic P-1 and monoclinic Cc space groups, respectively, with one structural unit per asymmetric part. In A and B, the prazosin molecule adopts different conformations, which do not correspond to those obtained by DFT optimizations of protonated and free prazosin.

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