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Structural characterization of anhydrous naloxone- and naltrexone hydrochloride by high resolution laboratory X-ray powder diffraction and thermal analysis

✍ Scribed by Kunihisa Sugimoto; Robert E. Dinnebier; Marek Zakrzewski

Publisher: John Wiley and Sons
Year: 2007
Tongue: English
Weight: 441 KB
Volume: 96
Category: Article
ISSN: 0022-3549
DOI: 10.1002/jps.20972

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✦ Synopsis

The crystal structures of the analgesic compounds anhydrous naloxone and naltrexone hydrochloride were determined ab initio from high resolution laboratory X-ray powder diffraction data. Both compounds crystallize in the orthorhombic space group P2 1 2 1 2 1 with lattice parameters of a ¼ 14.6588(10) A ˚, b ¼ 17.4363(9) A ˚, c ¼ 7.96200(22) A ˚, and V ¼ 2035.06(23) A ˚3 for naloxone hydrochloride and a ¼ 15.4560(5) A ˚, b ¼ 14.9809(4) A ˚, c ¼ 7.84121(18) A ˚, and V ¼ 1815.58(11) A ˚3 for naltrexone hydrochloride. The crystal structure of anhydrous naloxone hydrochloride forms one-dimensional chains through hydrogen bonds. In the crystal structure of anhydrous naltrexone hydrochloride, two-dimensional sheets are formed by hydrogen bonds. The dehydration processes of naloxone hydrochloride dehydrate and naltrexone hydrochloride tetrahydrate was analyzed by DTA, DSC, TG, and MG.

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