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Structural Characterization and Immunogenicity in Wild-Type and Immune Tolerant Mice of Degraded Recombinant Human Interferon Alpha2b

โœ Scribed by Suzanne Hermeling; Liliana Aranha; J. Mirjam A. Damen; Monique Slijper; Huub Schellekens; Daan J. A. Crommelin; Wim Jiskoot

Publisher
Springer US
Year
2005
Tongue
English
Weight
492 KB
Volume
22
Category
Article
ISSN
0724-8741

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Antibody response to aggregated human interferon alpha2b in wild-type and transgenic immune tolerant mice depends on type and level of aggregation
โœ Suzanne Hermeling; Huub Schellekens; Coen Maas; Martijn F.B.G. Gebbink; Daan J.A ๐Ÿ“‚ Article ๐Ÿ“… 2006 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 301 KB

The aim of this study was to determine the sensitivity of transgenic immune tolerant mice for the type and level of aggregation of recombinant human interferon alpha2b (rhIFNa2b). RhIFNa2b was aggregated by metal-catalyzed oxidation or by incubation at elevated temperature and various pHs. Native rh