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Structural Characterization and Computer-Aided Optimization of a Small-Molecule Inhibitor of the Arp2/3 Complex, a Key Regulator of the Actin Cytoskeleton

✍ Scribed by Andrew W. Baggett; Dr. Zoe Cournia; Min Suk Han; Dr. George Patargias; Dr. Adam C. Glass; Prof. Shih-Yuan Liu; Prof. Brad J. Nolen

Book ID
112066700
Publisher
John Wiley and Sons
Year
2012
Tongue
English
Weight
985 KB
Volume
7
Category
Article
ISSN
1860-7179

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## Abstract Pancreatic cancer is a highly aggressive malignancy and one of the leading causes of cancer deaths, mainly due to the lack of methods for early diagnosis and the lack of effective therapies. Recent CGH microarray studies have revealed several regions that are recurrently amplified in pa