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Structural Changes in the Lectin Domain of CD23, the Low-Affinity IgE Receptor, upon Calcium Binding

✍ Scribed by Beth A. Wurzburg; Svetlana S. Tarchevskaya; Theodore S. Jardetzky


Book ID
113918658
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
462 KB
Volume
14
Category
Article
ISSN
0969-2126

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Growth factor receptor-bound protein 2 (Grb2) is an extensively studied adaptor protein involved in cell signaling. Grb2 is a highly flexible protein composed of a single SH2 domain flanked by two SH3 domains. Here we report on the structural dynamic effects upon interaction of a phosphopeptide liga