Structural changes in the C-terminus of Ca2+-bound rat S100B(ββ) upon binding to a peptide derived from the C-terminal regulatory domain of p53

S100B(ββ) inhibits the protein kinase C-

S100B(ββ) inhibits the protein kinase C-dependent phosphorylation of a peptide derived from p53 in a Ca2+-dependent manner

✍ Paul T. Wilder; Richard R. Rustandi; Alexander C. Drohat; David J. Weber 📂 Article 📅 1998 🏛 Cold Spring Harbor Laboratory Press 🌐 English ⚖ 509 KB

## Abstract S100B(ββ) is a dimeric Ca^2+^‐binding protein that is known to inhibit the protein kinase C (PKC)‐dependent phosphorylation of several proteins. To further characterize this inhibition, we synthesized peptides based on the PKC phosphorylation domains of p53 (residues 367‐388), neuromodu