Structural Change in β-Sheet A of Z α1-Antitrypsin Is Responsible for Accelerated Polymerization and Disease

Conformational change from antiparallel

Conformational change from antiparallel β-sheet to α-helix in a series of depsipeptide, -(Leu-Leu-Lac)n-: Syntheses, spectroscopic studies, and crystal structures of Boc-Leu-Lac-OEt and Boc-(Leu-Leu-Lac)n-OEt (n = 1, 2)

✍ Hiroyuki Oku; Keiichi Yamada; Ryoichi Katakai 📂 Article 📅 2008 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 510 KB

## Abstract The depsipeptides Boc‐Leu‐Lac‐OEt (1) and Boc‐(Leu‐Leu‐Lac)~__n__~‐OEt (__n__ = 1, 2) (**2** and **3**, respectively) (Boc = __tert__‐butyloxycarbonyl, Lac = L‐lactic acid residue) has been synthesized and studied by crystallographic, CD spectroscopic, and ESI‐MS analyses. In the packin