Structural Biology and Functional Genomics

✍ Scribed by T. Cavalier-Smith, M. J. Beaton (auth.), E. Morton Bradbury, Sándor Pongor (eds.)

• Publisher: Springer Netherlands
• Year: 1999
• Tongue: English
• Leaves: 310
• Series: NATO Science Series 71
• Edition: 1
• Category: Library

✦ Synopsis

Biomedical research will be revolutionised by the current efforts to sequence the human genome and the genomes of model organisms. Of the newly sequenced genes, 50% code for proteins of unknown functions, while as little as 5% of sequences in mammalian genomes code for proteins. New, genome-wide approaches are needed to draw together the knowledge that is emerging simultaneously in a number of fields of genome research.
This volume is a high-level survey of the newly emerging concepts of structural biology and functional genomics for biologists, biochemists and medical researchers interested in genome research. Topics included are chromosome and chromatin organisation, novel DNA and RNA structures, DNA flexibility, supercoiling, prediction of protein functions, strategies for large scale structural analysis, and computer modelling.

✦ Table of Contents

Front Matter....Pages i-ix
The Skeletal Function of Non-Genic Nuclear DNA: New Evidence from Ancient Cell Chimaeras....Pages 1-18
DNA Repeats in the Human Genome....Pages 19-51
Left-Handed Z-DNA: Structure and Function....Pages 53-72
Superhelical DNA Studied by Solution Scattering and Computer Models....Pages 73-85
Micro-Mechanical Measurement of the Torsional Modulus of DNA....Pages 87-96
Sequence-Dependent Modelling of Local DNA Bending Phenomena: Curvature Prediction and Vibrational Analysis....Pages 97-114
Modelling DNA Stretching for Physics and Biology....Pages 115-131
Single-Chain 434 Repressors with Altered DNA-Binding Specificities....Pages 133-145
Fast Combinatorial Cartography by Fish on Combed Genomic DNA....Pages 147-149
RNA Folding and Catalysis....Pages 151-165
Histone-DNA Contacts in Structure/Function Relationships of Nucleosomes as Revealed by Crosslinking....Pages 167-189
The Role of Histone H1 in Chromatin Condensation and Transcriptional Repression....Pages 191-204
Chromatin Control of HIV-1 Gene Expression....Pages 205-216
Mechanisms of Separation of the Complementary Strands of DNA During Replication....Pages 217-233
Exploring Structure Space....Pages 235-249
The Protein Data Bank....Pages 251-264
Functional Genomics and Enzyme Evolution....Pages 265-283
The Beamlines of Elettra and Their Application to Structural Biology....Pages 285-301
Back Matter....Pages 303-313

✦ Subjects

Life Sciences, general; Medicine/Public Health, general; Chemistry/Food Science, general