Structural Bioinformatics of Membrane Proteins

✍ Scribed by Prof. Dmitrij Frishman (auth.)

• Publisher: Springer-Verlag Wien
• Year: 2010
• Tongue: English
• Leaves: 286
• Edition: 1
• Category: Library

✦ Synopsis

This book is the first one specifically dedicated to the structural bioinformatics of membrane proteins. With a focus on membrane proteins from the perspective of bioinformatics, the present work covers a broad spectrum of topics in evolution, structure, function, and bioinformatics of membrane proteins focusing on the most recent experimental results. Leaders in the field who have recently reported breakthrough advances cover algorithms, databases and their applications to the subject.

The increasing number of recently solved membrane protein structures makes the expert coverage presented here very timely.

Structural bioinformatics of membrane proteins has been an active area of research over the last thee decades and proves to be a growing field of interest.

✦ Table of Contents

Front Matter....Pages I-XI
Evolutionary origins of membrane proteins....Pages 1-28
Molecular archeological studies of transmembrane transport systems....Pages 29-43
Resource for structure related information on transmembrane proteins....Pages 45-59
Topology prediction of membrane proteins: how distantly related homologs come into play....Pages 61-82
Transmembrane beta-barrel protein structure prediction....Pages 83-102
Multiple alignment of transmembrane protein sequences....Pages 103-122
Prediction of re-entrant regions and other structural features beyond traditional topology models....Pages 123-136
Dual-topology: one sequence, two topologies....Pages 137-150
Predicting the burial/exposure status of transmembrane residues in helical membrane proteins....Pages 151-164
Helix-helix interaction patterns in membrane proteins....Pages 165-186
Predicting residue and helix contacts in membrane proteins....Pages 187-203
Natural constraints, folding, motion, and structural stability in transmembrane helical proteins....Pages 205-229
Prediction of three-dimensional transmembrane helical protein structures....Pages 231-249
GPCRs: Past, present, and future....Pages 251-278
Back Matter....Pages 279-281

✦ Subjects

Computational Biology/Bioinformatics; Systems Biology; Theoretical and Computational Chemistry