𝔖 Bobbio Scriptorium
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Structural bioinformatic approaches to understand cross-reactivity

✍ Scribed by Heimo Breiteneder; Clare Mills

Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
305 KB
Volume
50
Category
Article
ISSN
1613-4125

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✦ Synopsis

Abstract

Cross‐reactivity of allergens results from the presence of antibody‐accessible conserved surface structures. These can best be studied when allergens have been structurally defined by X‐ray crystallography or another structure determination method. When this is not the case, mimotope technology provides a useful alternative for elucidating antibody‐binding sites on allergens. Structural bioinformatic approaches have been used to study the cross‐reactivity of inhalant allergens with labile food allergens (Bet v 1 family) as well as the cross‐reactivity between stable food allergens such as members of the nonspecific lipid transfer protein family. It was found that the degree of similarity of the structures correlated with the observed IgE cross‐reactivities. However, IgE cross‐reactivity between structurally unrelated allergens has not been demonstrated to date.

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