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Structural basis of the fibrinogen–fibrin transformation: contributions from X-ray crystallography

✍ Scribed by Russell F Doolittle

Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
376 KB
Volume
17
Category
Article
ISSN
0268-960X

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✦ Synopsis

During the past several years, a number of crystal structures have been determined of fragments from fibrinogen and fibrin and, most recently, a structure of a native fibrinogen. One feature of the fibrinogen molecule that has emerged from these studies has to do with its "loose ends," segments of the molecule that are extremely mobile and not discernable by X-ray crystallography. Some, if not all, of this flexibility is functionally important. Small synthetic peptides based on mobile parts of fibrinogen exposed by the action of thrombin have contributed significantly to these studies and may yet prove useful therapeutically. In the end, although crystal structures have added greatly to our understanding of fibrin formation, much still needs to be unraveled about how clots form.

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