Structural Basis of the Activity of the Microtubule-Stabilizing Agent Epothilone A Studied by NMR Spectroscopy in Solution

Structural Basis of the Activity of the

✍ Marcel Reese; Víctor M. Sánchez-Pedregal; Karel Kubicek; Jens Meiler; Marcel J. 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 445 KB

ChemInform Abstract: Chemical Synthesis

ChemInform Abstract: Chemical Synthesis and Biological Studies of the Epothilones: Microtubule Stabilizing Agents with Enhanced Activity Against Multidrug-Resistant Cell Lines and Tumors

✍ Christina R. Harris; Scott D. Kuduk; Samuel J. Danishefsky 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 25 KB 👁 2 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v

The High-Resolution Solution Structure o

The High-Resolution Solution Structure of Epothilone A Bound to Tubulin: An Understanding of the Structure–Activity Relationships for a Powerful Class of Antitumor Agents

✍ Teresa Carlomagno; Marcel J. J. Blommers; Jens Meiler; Wolfgang Jahnke; Thomas S 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 122 KB 👁 2 views

Most of the drugs available today for the treatment of cancer are based on the inhibition of cell proliferation and induction of cell death by apoptosis. At the molecular level, the majority of cytotoxic agents interfere with DNA function. However, a prominent subclass of compounds, including paclit

The High-Resolution Solution Structure o

The High-Resolution Solution Structure of Epothilone A Bound to Tubulin: An Understanding of the Structure–Activity Relationships for a Powerful Class of Antitumor Agents

✍ Teresa Carlomagno; Marcel J. J. Blommers; Jens Meiler; Wolfgang Jahnke; Thomas S 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 122 KB 👁 2 views

Most of the drugs available today for the treatment of cancer are based on the inhibition of cell proliferation and induction of cell death by apoptosis. At the molecular level, the majority of cytotoxic agents interfere with DNA function. However, a prominent subclass of compounds, including paclit

The behavior of stainless steels in phys

The behavior of stainless steels in physiological solution containing complexing agent studied by X-ray photoelectron spectroscopy

✍ Milo?ev, Ingrid ;Strehblow, Hans-Henning 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 371 KB 👁 2 views

The passive film formed by electrochemical oxidation on two different stainless steels differing in molybdenum (Mo) content in physiological solution with and without the addition of complexing agent, i.e., citrate, was studied using X-ray photoelectron spectroscopy. The alloys were polarized at dif

Studies on the structure of γ-picoline b

Studies on the structure of γ-picoline by NMR in a nematic solution

✍ C.L Khetrapal; A Saupe 📂 Article 📅 1973 🏛 Elsevier Science ⚖ 347 KB