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Structural basis of m7GpppG binding to the nuclear cap-binding protein complex

✍ Scribed by Calero, Guillermo; Wilson, Kristin F.; Ly, Thi; Rios-Steiner, Jorge L.; Clardy, Jon C.; Cerione, Richard A.

Book ID
109965412
Publisher
Nature Publishing Group
Year
2002
Tongue
English
Weight
875 KB
Volume
9
Category
Article
ISSN
1072-8368

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## Abstract Signal transducer and activator of transcription 3 (Stat3) is constitutively active in a number of cancers where it participates in aberrant transcription of prosurvival, cell cycling, and angiogenesis genes. Since Stat3 initiates its signaling activity through binding of its SH2 domain