Structural Basis of Interaction between Urokinase-type Plasminogen Activator and its Receptor
β Scribed by Cyril Barinka; Graham Parry; Jennifer Callahan; David E. Shaw; Alice Kuo; Khalil Bdeir; Douglas B. Cines; Andrew Mazar; Jacek Lubkowski
- Book ID
- 116663265
- Publisher
- Elsevier Science
- Year
- 2006
- Tongue
- English
- Weight
- 952 KB
- Volume
- 363
- Category
- Article
- ISSN
- 0022-2836
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## Abstract Urokinase plasminogen activator (uPA) and its receptor (uPAR) are overexpressed in various neoplasms, and play a key role in tumor progression and metastasis. In this study, we examined uPA and uPAR expression in a variety of human breast cancer cell lines and found that lines with elev
A sandwich-type ELISA has been developed for the assessment of complexes between urokinase-type plasminogen activator (uPA) and its receptor (uPAR) in extracts of squamous cell lung carcinomas. The assay is based on a combination of rabbit polyclonal anti-uPA antibodies and a biotinylated mouse anti