Structural Basis for Triclosan and NAD Binding to Enoyl-ACP Reductase of Plasmodium falciparum
β Scribed by Kaza Suguna; Avadhesha Surolia; Namita Surolia
- Book ID
- 115587822
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- English
- Weight
- 110 KB
- Volume
- 283
- Category
- Article
- ISSN
- 0006-291X
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## Abstract A structureβbased approach has been adopted to develop 2β²βsubstituted analogs of triclosan. The Cl at position 2β² in ring B of triclosan was chemically substituted with other functional groups like NH~2~, NO~2~ and their inhibitory potencies against __Pf__ENR were determined. The bindin
## Abstract Enoyl acyl carrier protein reductase (ENR), which catalyzes the final and rate limiting step of fatty acid elongation, has been validated as a potential drug target. Triclosan is known to be an effective inhibitor for this enzyme. We mutated the substrate binding site residue Ala372 of