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Structural Basis for the Modulation of the Neuronal Voltage-Gated Sodium Channel NaV1.6 by Calmodulin

โœ Scribed by Chichili, Vishnu Priyanka Reddy; Xiao, Yucheng; Seetharaman, J.; Cummins, Theodore R.; Sivaraman, J.

Book ID
120882758
Publisher
Springer Science and Business Media LLC
Year
2013
Tongue
English
Weight
901 KB
Volume
3
Category
Article
ISSN
2045-2322

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## Abstract The sodium channel gene __Scn8a__ encodes the channel Na~V~1.6, which is widely distributed in the central and peripheral nervous system. Na~V~1.6 is the major channel at the nodes of Ranvier in myelinated axons. Mutant alleles of mouse __Scn8a__ result in neurological disorders includi