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Structural Basis for the Improved Potency of Peroxisome Proliferator-Activated Receptor (PPAR) Agonists

✍ Scribed by Yi-Hui Peng; Dr. Mohane Selvaraj Coumar; Jiun-Shyang Leou; Jian-Sung Wu; Dr. Hui-Yi Shiao; Dr. Chia-Hui Lin; Dr. Wen-Hsing Lin; Tzu Wen Lien; Dr. Xin Chen; Dr. John T.-A. Hsu; Dr. Yu-Sheng Chao; Dr. Chien-Fu Huang; Dr. Ping-Chiang Lyu; Dr. Hsing-Pang Hsieh; Dr. Su-Ying Wu

Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
689 KB
Volume
5
Category
Article
ISSN
1860-7179

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## Abstract The peroxisome proliferator‐activated receptor‐α (PPAR‐α) plays a key role in lipid metabolism and inflammation. Recently, we demonstrated that administration of the PPAR‐α agonists gemfibrozil and fenofibrate, inhibit the clinical signs of experimental autoimmune encephalomyelitis (EAE