Structural basis for the binding of high
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John S. McMurray
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Article
📅
2007
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Wiley (John Wiley & Sons)
🌐
English
⚖ 451 KB
## Abstract Signal transducer and activator of transcription 3 (Stat3) is constitutively active in a number of cancers where it participates in aberrant transcription of prosurvival, cell cycling, and angiogenesis genes. Since Stat3 initiates its signaling activity through binding of its SH2 domain