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Structural basis for the broad-spectrum inhibition of metallo-β-lactamases by thiols

✍ Scribed by Karsisiotis, Andreas I.; Damblon, Christian; Lassaux, Patricia; Papamicael, Cyril; Roberts, Gordon C. K.; Galleni, Moreno; Dideberg, Otto; Liénard, Benoît M. R.; Garau, Gianpiero; Horsfall, Louise


Book ID
111954101
Publisher
Royal Society of Chemistry
Year
2008
Tongue
English
Weight
744 KB
Volume
6
Category
Article
ISSN
1477-0520

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Crystal structure of New Delhi metallo-β
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## Abstract β‐Lactams are the most commonly prescribed class of antibiotics and have had an enormous impact on human health. Thus, it is disquieting that an enzyme called New Delhi metallo‐β‐lactamase‐1 (NDM‐1) can confer Enterobacteriaceae with nearly complete resistance to all β‐lactam antibiotic