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Structural Basis for the Autoinhibition of c-Abl Tyrosine Kinase

✍ Scribed by Bhushan Nagar; Oliver Hantschel; Matthew A. Young; Klaus Scheffzek; Darren Veach; William Bornmann; Bayard Clarkson; Giulio Superti-Furga; John Kuriyan


Book ID
117269467
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
748 KB
Volume
112
Category
Article
ISSN
0092-8674

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Conformational searches on three closely related pp60 c-src protein tyrosine kinase inhibitors of varying potencies were performed to determine a structural basis for their activity. The first was a linear peptide (PDNEYAFFQf), the second its 10-membered cyclic analogue, and the third a cyclic analo