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Structural basis for the anticoagulant activity of the thrombin–thrombomodulin complex

✍ Scribed by Fuentes-Prior, Pablo; Iwanaga, Yoriko; Huber, Robert; Pagila, Rene; Rumennik, Galina; Seto, Marian; Morser, John; Light, David R.; Bode, Wolfram

Book ID
109768140
Publisher
Nature Publishing Group
Year
2000
Tongue
English
Weight
797 KB
Volume
404
Category
Article
ISSN
0028-0836

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Protein C (PC) is activated to an essential anticoagulant enzyme (activated PC or APC) by thrombin (T) bound to thrombomodulin (TM), a membrane receptor present on the surface of endothelial cells. The understanding of this complex biological system is in part limited due to the lack of integration