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Structural basis for a disfavored elimination reaction in catalytic antibody 1D4

✍ Scribed by Nicholas A Larsen; Andreas Heine; Laura Crane; Benjamin F Cravatt; Richard A Lerner; Ian A.Wilson


Book ID
115631442
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
522 KB
Volume
314
Category
Article
ISSN
0022-2836

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## Abstract Analysis of the structural and functional requirements within the asymmetric peptidic catalyst H‐D‐Pro‐Pro‐Asp‐NH~2~ led to the development of the closely related peptide H‐D‐Pro‐Pro‐Glu‐NH~2~ as an even more efficient catalyst for asymmetric conjugate addition reactions of aldehydes to