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Structural basis behind the interaction of Zn2 + with the protein α-synuclein and the Aβ peptide: A comparative analysis

✍ Scribed by Ariel A. Valiente-Gabioud; Valentina Torres-Monserrat; Laura Molina-Rubino; Andres Binolfi; Christian Griesinger; Claudio O. Fernández


Book ID
119298890
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
927 KB
Volume
117
Category
Article
ISSN
0162-0134

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✍ Luisa Ronga; Pasquale Palladino; Gabriella Saviano; Teodorico Tancredi; Ettore B 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 192 KB

## Abstract The 173–195 segment corresponding to the helix 2 of the globular PrP domain is a good candidate to be one of the several ‘spots’ of intrinsic structural flexibility, which might induce local destabilization and concur to protein transformation, leading to aggregation‐prone conformations