Structural Aspects of Troponin-Tropomyosin Regulation of Skeletal Muscle Contraction

✍ Scribed by Zot, A S; Potter, J D

• Book ID: 120807936
• Publisher: Annual Reviews
• Year: 1987
• Tongue: English
• Weight: 914 KB
• Volume: 16
• Category: Article
• ISSN: 0883-9182
• DOI: 10.1146/annurev.bb.16.060187.002535

✦ Synopsis

Muscle contraction is initiated by an increase in the intracellular free Ca2+ concentration. In skeletal muscle, the rise in intracellular free Ca2+ is produced by release of Ca2+ from the sarcoplasmic reticulum. Skeletal muscle contraction is then regulated by the binding of Ca2+ to troponin, a regulatory protein found in the thin fi lament of the myofibril . Troponin (Tn) consists of three different subunits (TnI, TnT, and TnC) and is located periodically along the thin filament with the protein tro-535