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Structural and Thermodynamic Characterization of the Interaction of the SH3 Domain from Fyn with the Proline-Rich Binding Site on the p85 Subunit of PI3-Kinase †

✍ Scribed by Renzoni, D. A.; Pugh, D. J. R.; Siligardi, G.; Das, P.; Morton, C. J.; Rossi, C.; Waterfield, M. D.; Campbell, I. D.; Ladbury, J. E.


Book ID
127354516
Publisher
American Chemical Society
Year
1996
Tongue
English
Weight
495 KB
Volume
35
Category
Article
ISSN
0006-2960

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X-linked agammaglobulinemia (XLA), an inherited disease, is caused by mutations in the Bruton's tyrosine kinase (BTK). The absence of functional BTK leads to failure of B-cell differentiation; this incapacitates antibody production in XLA patients, who suffer from recurrent, sometimes lethal, bacter