Structural and thermodynamic analysis of heteroassociation of daunomycin and flavin mononucleotide molecules in water by1H NMR spectroscopy
โ Scribed by M. P. Evstigneev; A. O. Rozvadovskaya; A. S. Chubarov; A. A. Hernandez Santiago; D. B. Davies; A. N. Veselkov
- Publisher
- SP MAIK Nauka/Interperiodica
- Year
- 2005
- Tongue
- English
- Weight
- 172 KB
- Volume
- 46
- Category
- Article
- ISSN
- 0022-4766
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The complexation of antitumour antibiotics novatrone (NOV) and daunomycin (DAU) in aqueous solution has been studied by one-and two-dimensional 1 H-NMR spectroscopy (500 MHz) in order to elucidate the probable molecular mechanism of the action of aromatic antitumour drugs in combination chemotherapy
ุ1 , respectively. The results for the residual dipolar interactions were verified by repeating the above measurements at a temperature of 1.5ยฐC, where the spectra of the H 2 O molecules were well resolved, so that the 1 H-1 H dipolar interaction could be determined directly from the observed splitt