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Structural and molecular changes along the continuum of Alzheimer's disease

✍ Scribed by Rik Ossenkoppele; Hugo Vrenken; Nelleke Tolboom; Adriaan Versteeg; Ronald van Schijndel; Maqsood Yaqub; Ronald Boellaard; Wiesje Van der Flier; Frederik Barkhof; Adriaan Lammertsma; Philip Scheltens; Bart N.M. van Berckel

Book ID
118467036
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
295 KB
Volume
7
Category
Article
ISSN
1552-5260

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## Abstract Regional and global cerebral atrophy are inevitable features of Alzheimer's disease (AD). We assessed volumes and atrophy rates of brain structures in patients with familial AD during the period that they developed symptoms. Five patients with presymptomatic AD and 20 controls had two o