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Structural and biochemical characterization of the KRLB region in insulin receptor substrate-2

✍ Scribed by Wu, Jinhua; Tseng, Yolanda D; Xu, Chong-Feng; Neubert, Thomas A; White, Morris F; Hubbard, Stevan R


Book ID
109965516
Publisher
Nature Publishing Group
Year
2008
Tongue
English
Weight
607 KB
Volume
15
Category
Article
ISSN
1545-9993

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## Abstract Translocation of the insulin receptor substrate‐1 (IRS‐1) to the nuclei has been reported to occur in cells stimulated by insulin‐like growth factor‐1 (IGF‐I) or expressing certain viral and cellular oncogenes. We show here that insulin can also induce nuclear translocation of IRS‐1 in