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Structural and biochemical characterization of a novel Mn2+-dependent phosphodiesterase encoded by the yfcE gene

✍ Scribed by Darcie J. Miller; Ludmilla Shuvalova; Elena Evdokimova; Alexei Savchenko; Alexander F. Yakunin; Wayne F. Anderson


Book ID
111752951
Publisher
Cold Spring Harbor Laboratory Press
Year
2007
Tongue
English
Weight
888 KB
Volume
16
Category
Article
ISSN
0961-8368

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PAD4 is a peptidylarginine deiminase that catalyzes citrullination, a type of post-translational modification. In this reaction, arginine residues in proteins are converted to citrulline. PAD4 promotes the deimination of arginine residues in histones and may regulate transcription in the context of