Structural and biochemical analyses of t
Structural and biochemical analyses of the human PAD4 variant encoded by a functional haplotype gene
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Horikoshi, Naoki ;Tachiwana, Hiroaki ;Saito, Kengo ;Osakabe, Akihisa ;Sato, Mamo
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Article
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2011
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International Union of Crystallography
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English
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PAD4 is a peptidylarginine deiminase that catalyzes citrullination, a type of post-translational modification. In this reaction, arginine residues in proteins are converted to citrulline. PAD4 promotes the deimination of arginine residues in histones and may regulate transcription in the context of