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Structural and analytical characterization of three hydrates and an anhydrate form of risedronate

✍ Scribed by Nancy Redman-Furey; Michael Dicks; Adrienne Bigalow-Kern; R. Thomas Cambron; Gwen Lubey; Cathy Lester; Dana Vaughn

Book ID: 102911250
Publisher: John Wiley and Sons
Year: 2005
Tongue: English
Weight: 753 KB
Volume: 94
Category: Article
ISSN: 0022-3549
DOI: 10.1002/jps.20308

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✦ Synopsis

Four hydration states are reported for Risedronate monosodium. A singlecrystal X-ray structure determination is provided as proof of assignment for the monohydrate, hemi-pentahydrate, and variable hydrate forms. The structure provided for the anhydrate form was determined through simulating annealing calculations and subsequent Reitveld refinement of a high-quality X-ray powder diffraction patterns Favorable comparisons of experimentally obtained X-ray powder patterns are made to those generated from the single crystal data. Characteristic infrared, Raman, and NMR spectra are provided and discussed for each form as are thermal analysis profiles. In addition, photomicrographs are provided for each of the forms isolated for this study. The hemi-pentahydrate is demonstrated to be the equilibrium form at room temperature and 378C, in the presence of water.

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