✦ LIBER ✦

Structural Analysis of Isoform-Specific Inhibitors Targeting the Tetrahydrobiopterin Binding Site of Human Nitric Oxide Synthases

✍ Scribed by Matter, Hans; Kumar, H. S. Arun; Fedorov, Roman; Frey, Armin; Kotsonis, Peter; Hartmann, Elisabeth; Fröhlich, Lothar G.; Reif, Andreas; Pfleiderer, Wolfgang; Scheurer, Peter; Ghosh, Dipak K.; Schlichting, Ilme; Schmidt, Harald H. H. W.

Book ID: 127319288
Publisher: American Chemical Society
Year: 2005
Tongue: English
Weight: 508 KB
Volume: 48
Category: Article
ISSN: 0022-2623
DOI: 10.1021/jm050007x

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

CO binding studies of nitric oxide synth

CO binding studies of nitric oxide synthase: effects of the substrate, inhibitors and tetrahydrobiopterin

✍ Hideaki Sato; Susumu Nomura; Ikuko Sagami; Osamu Ito; Simon Daff; Toru Shimizu 📂 Article 📅 1998 🏛 Elsevier Science 🌐 English ⚖ 116 KB

Stimulation of human nitric oxide syntha

Stimulation of human nitric oxide synthase by tetrahydrobiopterin and selective binding of the cofactor

✍ Peter Klatt; Burghard Heinzel; Bernd Mayer; Edda Ambach; Gabriele Werner-Felmaye 📂 Article 📅 1992 🏛 Elsevier Science 🌐 English ⚖ 261 KB

Inhibitors of human nitric oxide synthas

Inhibitors of human nitric oxide synthase isoforms with the carbamidine moiety as a common structural element

✍ William M. Moore; R. Keith Webber; Kam F. Fok; Gina M. Jerome; Christine M. Korn 📂 Article 📅 1996 🏛 Elsevier Science 🌐 English ⚖ 487 KB

Identification of potent and selective inhibitors of inducible nitric oxide synthase (NOS) is of great interest because of their therapeutic potential for treatment of diseases mediated by excess production of nitric oxide. We present here a comparison of potency and selectivity for amino acid and n

Structures of Tetrahydrobiopterin Bindin

Structures of Tetrahydrobiopterin Binding-Site Mutants of Inducible Nitric Oxide Synthase Oxygenase Dimer and Implicated Roles of Trp457 †,‡

✍ Aoyagi, Mika; Arvai, Andrew S.; Ghosh, Sanjay; Stuehr, Dennis J.; Tainer, John A 📂 Article 📅 2001 🏛 American Chemical Society 🌐 English ⚖ 621 KB

Active-Site Structure Analysis of Recomb

Active-Site Structure Analysis of Recombinant Human Inducible Nitric Oxide Synthase Using Imidazole

✍ Chabin, Renee M.; McCauley, Ermenegilda; Calaycay, Jimmy R.; Kelly, Theresa M.; 📂 Article 📅 1996 🏛 American Chemical Society 🌐 English ⚖ 419 KB

Computer Modeling of Selective Regions i

Computer Modeling of Selective Regions in the Active Site of Nitric Oxide Synthases: Implication for the Design of Isoform-Selective Inhibitors

✍ Ji, Haitao; Li, Huiying; Flinspach, Mack; Poulos, Thomas L.; Silverman, Richard 📂 Article 📅 2003 🏛 American Chemical Society 🌐 English ⚖ 617 KB