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Structural Analysis of Engineered Bb Fragment of Complement Factor B: Insights into the Activation Mechanism of the Alternative Pathway C3-Convertase

✍ Scribed by Karthe Ponnuraj; Yuanyuan Xu; Kevin Macon; Dwight Moore; John E Volanakis; Sthanam V.L Narayana


Book ID
117737397
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
706 KB
Volume
14
Category
Article
ISSN
1097-2765

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## A mechanism of activation of the alternative complement pathway by the classical pathway: protection of C3b from inactivation by covalent attachment to C4b* In this work we studied the role of the classical pathway complement component C4b in the activation of the alternative pathway. It was fo