✦ LIBER ✦

Structural alterations of enkephalins in the presence of GM1 ganglioside micelles

✍ Scribed by Chiradip Chatterjee; Chaitali Mukhopadhyay

Publisher: Wiley (John Wiley & Sons)
Year: 2003
Tongue: English
Weight: 219 KB
Volume: 70
Category: Article
ISSN: 0006-3525
DOI: 10.1002/bip.10509

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✦ Synopsis

Abstract

The enkephalins are endogenous neurotransmitters and bind with high affinity at the δ‐receptor. Gangliosides, the major glycans of nerve cells, known to interact both with receptors and ligands on the cell surface, have been implicated to modulate the actions of opioid receptors by allosteric regulation (Wu, G.; Lu, Z. H.; Wei, T. J.; Howells, R. D.; Christoffers, K.; Leeden R. W. Ann NY Acad Sci 1998, 845, 126–138). We have studied the interactions between enkephalins and monosialylated ganglioside GM1 using NMR spectroscopy and fluorescence. The structural models of enkephalins in the presence of GM1 micelles were generated using two‐dimensional ^1^H‐ROESY experiments along with restrained molecular dynamics simulations. We report a conformational alteration of enkephalins in the presence of GM1 micelles. © 2003 Wiley Periodicals, Inc. Biopolymers 70: 512–521, 2003

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