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Structural adaptability in the ligand-binding pocket of the ecdysone hormone receptor

✍ Scribed by Billas, Isabelle M. L.; Iwema, Thomas; Garnier, Jean-Marie; Mitschler, André; Rochel, Natacha; Moras, Dino

Book ID
109892500
Publisher
Nature Publishing Group
Year
2003
Tongue
English
Weight
744 KB
Volume
426
Category
Article
ISSN
0028-0836

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The ligand-binding domain (LBD) encompassing the C-terminal parts of the D- and the complete E-domains of the ecdysteroid receptor (EcR) fused to Gal4(AD) is present in two high molecular weight complexes (600 and 150 kDa) in yeast extracts according to size exclusion chromatography (Superdex 200 HR