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Strong synergistic induction of CYP1A1 expression by andrographolide plus typical CYP1A inducers in mouse hepatocytes

✍ Scribed by Atika Jaruchotikamol; Kanokwan Jarukamjorn; Wanna Sirisangtrakul; Tsutomu Sakuma; Yuki Kawasaki; Nobuo Nemoto


Book ID
113924184
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
380 KB
Volume
224
Category
Article
ISSN
0041-008X

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Carbofuran is a nematicide used in agricultural fields throughout the world. Indiscriminate use of this pesticide poses severe detrimental effects on our ecosystem. We have shown that it induces the CYP1A (cytochrome P4501A) monooxygenase enzyme system in cultured hepatocytes from Indian catfish, He