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Strong linkage on 2q33.3 to familial early-onset generalized osteoarthritis and a consideration of two positional candidate genes

โœ Scribed by Meulenbelt, Ingrid; Min, Josine L; van Duijn, Cornelia M; Kloppenburg, Margreet; Breedveld, Ferdinand C; Slagboom, P Eline


Book ID
110026705
Publisher
Nature Publishing Group
Year
2006
Tongue
English
Weight
153 KB
Volume
14
Category
Article
ISSN
1018-4813

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โœ Nechiporuk, A. ;Fain, P. ;Kort, E. ;Nee, L. E. ;Frommelt, E. ;Polinsky, R. J. ;K ๐Ÿ“‚ Article ๐Ÿ“… 1993 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 405 KB ๐Ÿ‘ 2 views

Alzheimer disease (AD) is a devastating neurodegenerative disease leading to global dementia. In addition to sporadic forms of AD, familial forms (FAD) have been recognized. Mutations in the amyloid precursor protein (APP) gene on chromosome (CHR) 21 have been shown to cause early-onset AD in a smal