✦ LIBER ✦
Strong genetic association between HLA-DR3 and a polymorphic variation in the regulatory region of theHSP70-1gene
✍ Scribed by Isabella Cascino; Rosa Sorrentino; Roberto Tosi
- Publisher
- Springer-Verlag
- Year
- 1993
- Tongue
- English
- Weight
- 546 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0093-7711
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✦ Synopsis
A three-allele polymorphic system is detectable by direct electrophoretic analysis of the amplified 5' untranslated und 5' flanking regions of the HLA-linked HSP70-1 gene. Single nucleotide differences at two sites, i.e., -110 and + 120, are responsible for changes in the bending pattern and, consequently, in the electrophoretic mobility of the three alleles. The presence of the sequence AAACCCC around position -110 is strongly associated with DR3.