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Strong association of a novel Tau promoter haplotype in progressive supranuclear palsy

โœ Scribed by Rohan de Silva; Markus Weiler; Huw R Morris; Eden R Martin; Nicholas W Wood; Andrew J Lees

Book ID
117472020
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
84 KB
Volume
311
Category
Article
ISSN
0304-3940

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๐Ÿ“œ SIMILAR VOLUMES

Relationship of the extended tau haploty
Relationship of the extended tau haplotype to tau biochemistry and neuropathology in progressive supranuclear palsy
โœ Wan-Kyng Liu; Tien V. Le; Jennifer Adamson; Matthew Baker; Natalie Cookson; John ๐Ÿ“‚ Article ๐Ÿ“… 2001 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 880 KB

Two extended haplotypes of the tau gene (H1 and H2) have been described. The frequency of H1 haplotype is increased in progressive supranuclear palsy (PSP). PSP is associated with filamentous tau lesions in neurons and glia, which are reportedly composed exclusively of tau isoforms with four repeats