✦ LIBER ✦

Stromal niches, plasma cell differentiation and survival

✍ Scribed by Katrin Moser; Koji Tokoyoda; Andreas Radbruch; Ian MacLennan; Rudolf A Manz

Publisher: Elsevier Science
Year: 2006
Tongue: English
Weight: 180 KB
Volume: 18
Category: Article
ISSN: 0952-7915
DOI: 10.1016/j.coi.2006.03.004

No coin nor oath required. For personal study only.

✦ Synopsis

Contacts made with other cells and stroma have a major impact on proliferation, differentiation, survival, migration and immunoglobulin class switching of plasma cell precursors as well as on the lifespan of the antibody-secreting cells. Induction of tissue-specific chemokine receptors and adhesion molecules directs migratory plasma cell precursors to tissues close to those in which the original immune stimulation occurred. This mechanism focuses the production of specific antibodies within a particular type of tissue, thus providing a means for the most efficient protection against tissue-specific pathogens. Relocation does not apply to long-lived plasma cells responsible for sustained titers of high-affinity systemic antibody. These are formed in germinal centers and migrate to specific niches in the bone marrow that support their further differentiation and long-term survival.

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