Stromal cell–dependent growth of B-1 B cell progenitors in the absence of direct contact
✍ Scribed by Montecino-Rodriguez, Encarnacion; Dorshkind, Kenneth
- Book ID
- 109945807
- Publisher
- Nature Publishing Group
- Year
- 2006
- Tongue
- English
- Weight
- 181 KB
- Volume
- 1
- Category
- Article
- ISSN
- 1750-2799
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Differentiation of B cell progenitors in vitro: generation of surface IgM' B cells, including Ly-1 B cells, from Thy-l-asialoGM1+ cells in newborn liver\* We have established a stromal adherent cell line (ST2) from fetal liver that promotes growth and differentiation of early B lineage cells. Many
## Analysis of mononuclear cells in the adult mouse liver revealed that B cells represent as much as half of the intrahepatic lymphocyte population. Intrahepatic B cells (IHB cells) are phenotypically similar to splenic B2 cells but express lower levels of CD23 and CD21 and higher levels of CD5. I