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Striatal neuronal apoptosis is preferentially enhanced by NMDA receptor activation in YAC transgenic mouse model of Huntington disease

โœ Scribed by Jacqueline Shehadeh; Herman B. Fernandes; Melinda M. Zeron Mullins; Rona K. Graham; Blair R. Leavitt; Michael R. Hayden; Lynn A. Raymond


Book ID
113811900
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
573 KB
Volume
21
Category
Article
ISSN
0969-9961

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We used two mouse models of Huntington's disease (HD) to examine changes in glutamate receptor sensitivity and striatal electrophysiology. One model, a transgenic, consisted of mice expressing exon 1 of the human HD gene and carrying 141-157 CAG repeat sequences (R6/2 line). The second model, a CAG