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Striatal gray matter loss in Huntington's disease is leftward biased

✍ Scribed by Mark Mühlau; Christian Gaser; Afra M. Wohlschläger; Adolf Weindl; Michael Städtler; Michael Valet; Claus Zimmer; Jan Kassubek; Alexander Peinemann

Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
129 KB
Volume
22
Category
Article
ISSN
0885-3185

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✦ Synopsis

Abstract

In Huntington's disease (HD), the distribution of pathological changes throughout the brain is incompletely understood. Some studies have identified leftward‐biased lateralization, whereas others did not. We performed magnetic resonance imaging and a voxel‐based asymmetry analysis in 44 right‐handed HD gene carriers (presymptomatic, n = 5; stage I, n = 28; stage II, n = 11) and 44 right‐handed healthy controls. The group comparison revealed leftward‐biased gray matter loss in the striatum. Further analyses showed no indication of asymmetry in presymptomatic HD patients but an increase in asymmetry in the course of the HD stages under examination. Our study demonstrates and discusses leftward‐biased gray matter loss in HD. © 2007 Movement Disorder Society

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