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Striatal dopaminergic metabolism is increased by deep brain stimulation of the subthalamic nucleus in 6-hydroxydopamine lesioned rats

✍ Scribed by Wassilios Meissner; Torsten Reum; Gesine Paul; Daniel Harnack; Reinhard Sohr; Rudolf Morgenstern; Andreas Kupsch

Book ID: 117471694
Publisher: Elsevier Science
Year: 2001
Tongue: English
Weight: 423 KB
Volume: 303
Category: Article
ISSN: 0304-3940
DOI: 10.1016/s0304-3940(01)01758-x

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## Abstract Deep brain stimulation of the subthalamic nucleus (STN‐DBS) has become an effective treatment option in advanced Parkinson's disease (PD). Recent animal studies showed an increase of neuronal firing in dopaminergic neurons under effective STN‐DBS. Increased striatal dopamine levels may