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Striatal dopamine and homovanillic acid in Huntington's Disease

✍ Scribed by G. P. Reynolds; N. J. Garrett

Publisher: Springer
Year: 1986
Tongue: English
Weight: 246 KB
Volume: 65
Category: Article
ISSN: 1435-1463
DOI: 10.1007/bf01256491

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## Abstract Huntington's disease (HD) is a progressive neurodegenerative disorder caused by an expanded CAG repeat region in exon 1 of the HD gene. This mutation results in the presence of an abnormally long polyglutamine tract in the encoded protein, huntingtin (htt). A major question in this fiel