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Striatal Delivery of Neurturin by CERE-120, an AAV2 Vector for the Treatment of Dopaminergic Neuron Degeneration in Parkinson's Disease

✍ Scribed by Gasmi, Mehdi; Herzog, Christopher D; Brandon, Eugene P; Cunningham, Justine J; Ramirez, G Anthony; Ketchum, Elias T; Bartus, Raymond T


Book ID
118154238
Publisher
Nature Publishing Group
Year
2007
Tongue
English
Weight
216 KB
Volume
15
Category
Article
ISSN
1525-0016

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Striatal delivery of CERE-120, an AAV2 v
✍ Christopher D. Herzog; Biplob Dass; James E. Holden; James Stansell III; Mehdi G 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 477 KB

## Abstract Neurturin (NTN) is a potent survival factor for midbrain dopaminergic neurons. CERE‐120, an adeno‐associated virus type 2 (AAV2) vector encoding human NTN (AAV2‐NTN), is currently being developed as a potential therapy for Parkinson's disease. This study examined the bioactivity and saf